ENCOMPASS is an international initiative focused on advancing prostate brachytherapy through coordinated data collection, collaborative research, and methodological innovation.
ENCOMPASS is a collaborative international consortium bringing together clinicians, medical physicists, and researchers to improve the quality, consistency, and outcomes of prostate brachytherapy.
The initiative integrates multi-centre clinical data, imaging, and treatment information with methodological development across areas such as image guidance, dose accumulation, treatment verification, and outcome modelling.
Prostate brachytherapy is one of the most conformal methods of delivering curative-intent radiotherapy for prostate cancer. However, there remains substantial variation in how treatment is delivered across institutions, including differences in patient selection, imaging, planning, technique, dose prescription, and follow-up.
These variations are not consistently captured or linked to patient outcomes, limiting the ability to define best practice, benchmark treatment quality, and identify sources of avoidable toxicity or suboptimal disease control.
ENCOMPASS was established to address this gap by enabling large-scale, standardised evaluation of prostate brachytherapy practice and outcomes across centres.
Builds an international network of centres contributing shared expertise, clinical experience, and research capacity.
Develops scalable systems for harmonised clinical, imaging, treatment, toxicity, and outcome data capture.
Supports development and validation of new approaches in imaging, dosimetry, treatment verification, and outcome modelling.
The ENCOMPASS Registry is the central data platform underpinning the initiative. It captures detailed clinical, imaging, and treatment data across participating centres to enable robust evaluation of prostate brachytherapy practice and outcomes.
By linking technical delivery parameters with toxicity and oncologic outcomes, the registry supports benchmarking, quality improvement, and high-impact collaborative research.
Participation in the registry forms the primary entry point into the ENCOMPASS collaborative network.
ENCOMPASS is co-led by three consortium chairs with expertise across radiation oncology, medical physics, prostate brachytherapy, and international collaborative research.
Radiation Oncology Medical Physics Specialist
St George Hospital Cancer Care Centre, Australia
Radiation Oncologist
Gustave Roussy, Paris, France
Radiation Oncologist
Gustave Roussy, Paris, France
The initiative is coordinated through St George Hospital Cancer Care Centre, with international leadership from Gustave Roussy and collaboration across leading centres in radiation oncology, medical physics, imaging, urology, and translational research.
ENCOMPASS is actively expanding its international network. Centres interested in contributing to the registry and collaborative research program are encouraged to get in touch.
Express Interest in Participating